Determination of nimodipine in plasma by HPLC-MS/MS and pharmacokinetic application
نویسندگان
چکیده
منابع مشابه
Stereospecific determination of cis- and trans-resveratrol in rat plasma by HPLC: application to pharmacokinetic studies.
A simple, accurate, precise, specific and reproducible high-performance liquid chromatography (HPLC) method was developed for simultaneous determination of resveratrol isomers in rat plasma. Cis-resveratrol was made by exposure of a trans-resveratrol solution to sunlight for 5 days followed by separation by HPLC and identification by mass spectrometry (MS). The assay procedure involved simple l...
متن کاملDetermination of fenticonazole in human plasma by HPLC–MS/MS and its application to pharmacokinetic studies☆
Two simple and sensitive high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) methods were developed and validated for the determination of fenticonazole in human plasma after percutaneous and intravaginal administration. Mifepristone was used as an internal standard (IS), and simple protein precipitation by acetonitrile containing 2% acetic acid was utilized for extract...
متن کاملDetermination of voriconazole in human plasma by HPLC-ESI-MS and application to pharmacokinetic study.
A fast, sensitive, high-performance liquid chromatography-tandem mass spectrometry method was developed for the determination of voriconazole in human plasma. Carbamazepine was used as the internal standard and the sample pretreatment involved one-step protein precipitation. Chromatographic separation was conducted on an Ultimate C18 column with a mobile phase consisting of acetonitrile-water (...
متن کاملDetermination of sophoricoside in rat plasma by HPLC and its application to pharmacokinetic studies.
A simple, sensitive, selective and reproducible reversed-phase HPLC method was developed for the determination of sophoricoside in rat plasma after intravenous administration. Naringin was successfully used as internal standard (IS) for calibration. The chromatographic separation was accomplished on a reversed-phase C(18) column using acetonitrile-methanol-0.08% phosphoric acid (8:29:63, v/v/v)...
متن کاملDetermination of nimodipine in human plasma by HPLC-ESI-MS and its application to a bioequivalence study.
A simple, specific, and precise liquid chromatographic-electrospray ionization mass spectrometric (LC-ESI-MS) method has been developed for determination of nimodipine concentration in human plasma. The method involves the addition of 200 microL of saturated sodium bicarbonate (NaHCO(3)) solution to plasma to improve the extraction recovery, liquid-liquid extraction of nimodipine from plasma sa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Brazilian Journal of Pharmaceutical Sciences
سال: 2010
ISSN: 1984-8250
DOI: 10.1590/s1984-82502010000400008